Correlation of serum lipids with the severity of diabetic retinopathy

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Original Article

Author Details : Nada Nadeem Ansari, Abdul Waris, Adeeb Alam Khan, Sheelu Shafiq Siddiqi

Volume : 3, Issue : 4, Year : 2017

Article Page : 299-303

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Abstract

Purpose: To measure a correlation between serum lipids and the severity of diabetic retinopathy in patients reporting to a tertiary care diabetic and endocrinology center, in western Uttar Pradesh.
Method: A hospital-based, cross-sectional study conducted on 240 eyes of 120 diabetic patients presenting at our Institute of Ophthalmology. The ETDRS system was used to grade the severity of retinopathy and the serum lipid profile of each patient was procured. The data analysis was done with the help of SPSS version 16.0 using unpaired t-test, binary logistic regression analysis, one way analysis of variance (ANOVA) with Bonferroni post hoc tests.
Result: A significantly increased level of total cholesterol (p=0.02), TG (p=0.0001) and LDL (p=0.0001) was found among patients with DR than without DR. The total cholesterol was found to be significantly (p<0.05) lower among the patients with mild NPDR than mild-moderate PDR, and high risk PDR. The TG level was significantly (p<0.05) different among various stages of retinopathy. The HDL was significantly (p<0.05) higher among the patients with mild NPDR than mild-moderate PDR. Similarly, the LDL level was significantly (p<0.05) lower among the patients with mild NPDR than mild-moderate PDR.
Conclusion: An increased level of total cholesterol, TG and LDL was found among patients with DR than without DR. The levels of total cholesterol, TG and LDL were found to be significantly lower among the patients with mild NPDR than PDR. The HDL level was higher among the patients with mild NPDR than mild-moderate PDR.

Keywords: Diabetic retinopathy, HDL, LDL, Lipids, TG.

How to cite : Ansari N N, Waris A, Khan A A, Siddiqi S S, Correlation of serum lipids with the severity of diabetic retinopathy. IP Int J Ocul Oncol Oculoplasty 2017;3(4):299-303

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