- Visibility 312 Views
- Downloads 350 Downloads
- Permissions
- DOI 10.18231/j.ijooo.v.11.i.2.2
-
CrossMark
- Citation
Novel diagnostic and therapeutic measures in the field of ocular oncology: Current advances and future directions
- Author Details:
-
Shivam Dubey *
Personalized treatments and sophisticated diagnostics have led to significant advancements in ocular oncology.
Reviewing modern diagnostic and treatment approaches that are revolutionizing the treatment of ocular cancers.
Databases like PubMed, Scopus, and ClinicalTrials.gov were used to perform a narrative review.
OCTA, AI-based imaging, ctDNA analysis, and gene expression profiling are examples of new diagnostic techniques. These days, treatments include immunotherapy, gene therapy, nanomedicine, and plaque brachytherapy.
The developments mark a paradigm shift in patient care and improve accuracy and prognosis in ocular oncology.
References
- Yonekawa Y, Kim IK. Epidemiology and management of uveal melanoma. Hematol Oncol Clin North Am. 2012;26(6):1169–84.
- Naseripour M, Ghasemi Falavarjani K, Mirshahi R, Sedaghat A. Optical coherence tomography angiography (OCTA) applications in ocular oncology. Eye (Lond). 2020 Sep;34(9):1535–45.
- Neupane R, Gaudana R, Boddu SHS. Imaging Techniques in the Diagnosis and Management of Ocular Tumors: Prospects and Challenges. AAPS J. 2018;20(6):97.
- Kaliki S, Vempuluru VS, Ghose N, Patil G, Viriyala R, Dhara KK. Artificial intelligence and machine learning in ocular oncology: Retinoblastoma. Indian J Ophthalmol. 2023;71(2):424–30.
- Park JJ, Diefenbach RJ, Byrne N, Long GV, Scolyer RA, Gray ES, et al. Circulating Tumor DNA Reflects Uveal Melanoma Responses to Protein Kinase C Inhibition. Cancers (Basel). 2021;13(7):1740.
- Plasseraud KM, Wilkinson JK, Oelschlager KM, Poteet TM, Cook RW, Stone JF, et al. Gene expression profiling in uveal melanoma: Dubey / IP International Journal of Ocular Oncology and Oculoplasty 2025;11(2):45-49 49 technical reliability and correlation of molecular class with pathologic characteristics. Diagn Pathol. 2017;12(1):59.
- Jelski W, Mroczko B. MicroRNAs as Biomarkers of Brain Tumor. Cancer Manag Res. 2024;16:1353–61.
- Berry JL, Pike S, Shah R, Reid MW, Peng CC, Wang Y, et al. Aqueous Humor Liquid Biopsy as a Companion Diagnostic for Retinoblastoma: Implications for Diagnosis, Prognosis, and Therapeutic Options: Five Years of Progress. Am J Ophthalmol. 2024;263:188–205.
- Papakostas TD, Lane AM, Morrison M, Gragoudas ES, Kim IK. Long-term Outcomes After Proton Beam Irradiation in Patients With Large Choroidal Melanomas. JAMA Ophthalmol. 2017;135(11):1191–6.
- Brewington BY, Shao YF, Davidorf FH, Cebulla CM. Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions. Clin Ophthalmol. 2018;12:925–34.
- Kim DW, Anderson J, Patel SP. Immunotherapy for uveal melanoma. Melanoma Manag. 2016;3(2):125–35.
- Khalili JS, Yu X, Wang J, Hayes BC, Davies MA, Lizee G, et al. Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11- dependent manner. Clin Cancer Res. 2012;18(16):4345–55.
- Pareek A, Kumar D, Pareek A, Gupta MM, Jeandet P, Ratan Y, et al. Retinoblastoma: An update on genetic origin, classification, conventional to next-generation treatment strategies. Heliyon. 2024;10(12):e32844.
- Li S, Chen L, Fu Y. Nanotechnology-based ocular drug delivery systems: recent advances and prospects. J Nanobiotechnology. 2023;21(1):232.
- Dubey S, Ocular drug delivery systems and nanotechnology. IP Int J Ocul Oncol Oculoplasty 2024;10(4):179–87
- Manjandavida FP, Stathopoulos C, Zhang J, Honavar SG, Shields CL. Intra-arterial chemotherapy in retinoblastoma - A paradigm change. Indian J Ophthalmol. 2019;67(6):740–54.
- Munier FL, Gaillard MC, Balmer A, Beck-Popovic M. Intravitreal chemotherapy for vitreous seeding in retinoblastoma: Recent advances and perspectives. Saudi J Ophthalmol. 2013;27(3):147–
- Mallipatna A, Marino M, Singh AD. Genetics of Retinoblastoma. Asia Pac J Ophthalmol (Phila). 2016;5(4):260–4.
How to Cite This Article
Vancouver
Dubey S. Novel diagnostic and therapeutic measures in the field of ocular oncology: Current advances and future directions [Internet]. IP Int J Ocul Oncol Oculoplasty. 2025 [cited 2025 Oct 02];11(2):45-49. Available from: https://doi.org/10.18231/j.ijooo.v.11.i.2.2
APA
Dubey, S. (2025). Novel diagnostic and therapeutic measures in the field of ocular oncology: Current advances and future directions. IP Int J Ocul Oncol Oculoplasty, 11(2), 45-49. https://doi.org/10.18231/j.ijooo.v.11.i.2.2
MLA
Dubey, Shivam. "Novel diagnostic and therapeutic measures in the field of ocular oncology: Current advances and future directions." IP Int J Ocul Oncol Oculoplasty, vol. 11, no. 2, 2025, pp. 45-49. https://doi.org/10.18231/j.ijooo.v.11.i.2.2
Chicago
Dubey, S.. "Novel diagnostic and therapeutic measures in the field of ocular oncology: Current advances and future directions." IP Int J Ocul Oncol Oculoplasty 11, no. 2 (2025): 45-49. https://doi.org/10.18231/j.ijooo.v.11.i.2.2